The HtrA2/Omi Anti-Human Antibody (clone 1B3) from IBL- America is a Mouse Monoclonal antibody to HTRA2. This antibody recognizes Homo Sapiens, and Human antigen. The HtrA2/Omi Anti-Human Antibody (clone 1B3) has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
HtrA2/Omi is a mammalian serine protease at high temperatures and a chaperone at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP)-binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death